So you already know what premature ejaculation is, and how it can cause stress and relationship issues, but the good news is that there are a variety of treatments available to help manage it. 

In this article, Shag Longer will focus on the different medications that are available to help you last longer in bed. With the right treatment, you can regain control and enjoy a more satisfying sexual experience. So, let’s get into it and learn more about the different options out there!

Oral medication

In this section, we will be discussing the oral medications that are commonly used to treat premature ejaculation. We will discuss the effectiveness, side effects, and potential risks of these medications in detail to provide a comprehensive understanding of the options available for treating premature ejaculation. 

Additionally, we will also be talking about the specific usage instructions, as well as any drug interactions that patients should be aware of before starting these oral medications. It is important to note that these medications require a consultation with a medical professional, and they should be prescribed after a thorough assessment of the condition.


Selective serotonin reuptake inhibitors (SSRIs)

so you might have heard of selective serotonin reuptake inhibitors or SSRIs for short. They’re a class of medications that doctors often prescribe to treat depression, anxiety, and panic disorders. They work by increasing the levels of a chemical called serotonin in your brain, which helps regulate your mood.

But here’s something you might not know – SSRIs can also be used to treat premature ejaculation. SSRIs can help delay ejaculation by increasing the levels of serotonin in the brain, which helps regulate the timing of ejaculation.

Two examples of SSRIs that have been used to treat PE are dapoxetine and fluoxetine. Dapoxetine is a short-acting SSRI that was specifically developed and FDA-approved for the treatment of PE. While Fluoxetine is an SSRI that is FDA approved for the treatment of depression and other disorders but has also been found to be effective in treating PE as well.

Side effects

Side effects that can be associated with SSRIs include:

  • feeling agitated, shaky, or anxious.
  • feeling or being sick.
  • indigestion.
  • diarrhea or constipation.
  • loss of appetite and weight loss.
  • dizziness.
  • blurred vision.
  • dry mouth.
Recommended dosage

Remember dosage can always vary from person to person, so it’s important you speak to a healthcare provider to come up with a specific one for you but here are some general guidelines:

Fluoxetine – Taken daily or once a week (when taken daily: 10 to 40 mg, when taken weekly: 90 mg)

Dapoxetine – As needed, 1 to 3 hours before having sex (low dose: 30 mg high dose: 60 mg)


So, have you ever heard of tramadol? It’s a medication that helps with moderate to severe pain. It works by binding to the same receptors in your brain that other pain meds like morphine and codeine bind to, which increases the levels of certain chemicals in your brain and gives you relief from pain.

But here’s something you might not know – tramadol has also been found to be effective in treating premature ejaculation. In some studies patients who tried it reported lasting longer in bed, with a more enjoyable sex life. The idea is that tramadol delays ejaculation by increasing the levels of certain chemicals in the brain, like serotonin and norepinephrine, which helps regulate when you ejaculate. You take it orally, and it usually starts working within an hour.

But here’s the catch – tramadol is an opioid, and that means it can be addictive and can lead to physical dependence if you take it for a long time.

Side effects

It can also cause side effects like nausea, constipation, dizziness, and drowsiness. Long-term use of tramadol may also lead to more severe side effects such as seizures and liver damage. That’s why doctors usually only prescribe tramadol for PE if other treatments haven’t worked and only when closely monitored by a healthcare professional.


In the study conducted, they administered 100mg of tramadol 6-8 hours before sexual intercourse, but consulting a physician is recommended

Phosphodiesterase type-5 inhibitors (PDE5 inhibitors)

Phosphodiesterase type-5 inhibitors (PDE5 inhibitors) are a class of drugs that are primarily used to treat erectile dysfunction (ED). These medications work by inhibiting the action of an enzyme called phosphodiesterase-5 (PDE5), which leads to increased levels of a chemical called cyclic guanosine monophosphate (cGMP) in the smooth muscle of the penis. This increased cGMP leads to the relaxation of the smooth muscle and increased blood flow, which results in an erection.

Examples of PDE5 inhibitors include sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). these meds have also been found to be effective in treating premature ejaculation too. 

Scientists aren’t exactly sure how it works, but it seems like PDE5 inhibitors can help improve control over ejaculation. It’s important to note that these medications are only effective for men with erectile dysfunction, they require sexual stimulation to work, and they usually take around 30 to 60 minutes to start working after taking them.

It’s important to have a conversation with your doctor to make sure PDE5 inhibitors are safe for you to use, especially if you have any underlying conditions or are taking other medications.

Side effects

Like any medication, PDE5 inhibitors can cause side effects, such as headaches, flushing, nasal congestion, and vision disturbances. These side effects are usually mild and tend to go away within a few hours.


Dosage depends of tolerance and effectiveness. For Viagra the regular dose is 50 mg, ranging from 25 mg – 100 mg, taken orally 30 min – an hour before sexual intercourse. It is important to consult a physician.

Topical Anesthetics

I know a few guys who refuse to take any form of pills. So if premature ejaculation pills, aren’t for you that’s cool, there are other medications out there for you too! One alternative that can help in delaying ejaculation you may want to check out is topical anesthetics.

They’re meds that you apply to your skin as a cream or gel. They work by numbing the area they’re applied to and making it less sensitive. They’re often used to reduce pain or discomfort during medical procedures or to decrease sensitivity in certain areas of the body.

Topical anesthetics can also be used to treat premature ejaculation. They can be applied to the head of the penis to reduce sensitivity and delay ejaculation. Medications like lidocaine and prilocaine are examples of topical anesthetics that have been used for PE. You apply them around 20-30 minutes before sexual activity.

But, here’s the thing: while topical anesthetics can delay ejaculation, they can also reduce pleasure during sex and cause numbness or loss of sensation in the penis


Numbing cream

One form of topical anesthetic to possibly help with premature ejaculation is numbing cream. The effectiveness of numbing cream as a treatment for premature ejaculation has had mixed reviews from person to person. 

Some men have found it to be very helpful and have reported a significant improvement in their sexual performance, while others have not seen much benefit. As the results may vary, it may be worth trying numbing cream to see if it works for you.

The different types of creams available for premature ejaculation treatment include:

Lidocaine cream

The lidocaine cream contains the active ingredient of lidocaine, which is a local anesthetic. It blocks the transmission of nerve impulses in the area it is applied to, this can help in reducing sensation in the penis and may lead to improve premature ejaculation

Prilocaine cream

Prilocaine cream is mostly used for numbing the skin before procedures like injections or laser treatments. It can also be used as a way to reduce the sensation in the penis, this could help prevent premature ejaculation.

EMLA cream

The EMLA cream functions similarly by inhibiting the conduction of nerve impulses which leads to a reduction in the sensitivity of the penis. But it is different in its composition, it’s a topical anesthetic medication that is made up of a mix of lidocaine and prilocaine, both being local anesthetics.


If you’re someone who doesn’t like putting creams and gels all over your penis, don’t worry – there’s another option. You can always try using sprays that are made with the same ingredients as the creams and gels, but they’re a bit easier to apply. 

These sprays can have the same effects and help reduce sensitivity in the penis to potentially improve premature ejaculation. So, if don’t want to deal with the mess of creams and gels, check out these sprays as an alternative.

Check out this guide on how to apply delay sprays


You might be wondering how they have ended up in this section and how condoms help with pe? The reason is that there are actually condoms available that have the same topical anesthetics found in numbing creams. 

So instead of applying cream or gel, you can use the condom, which is less messy and easy to use. These condoms can help reduce sensation in the penis, leading to potentially improving premature ejaculation. So next time you go shopping for condoms, look out for the ones that have a little extra something to help you out in the bedroom. (they might be labeled Extended pleasure or Delay condoms)


Side effects

As with every medication, there are always some potential side effects. The main ones you should look out for from using all of the above include:

  • Redness
  • Skin irritation
  • Rash at the site of the application
  • Temporary numbness or tingling sensation in the treated area.
  • Allergic reactions

Deciding which one is best for you

So, now you’ve read about oral medications and topical creams as potential solutions, but you’re not quite sure which one is right for you. Let’s recap the pros and cons for you to decide for yourself!

First, let’s talk about oral meds. These little guys, like dapoxetine, tramadol, and fluoxetine, can work wonders by increasing certain neurotransmitters in the brain and delaying ejaculation. Plus, they’re easy to take and can be taken on demand. But, oral meds can also cause side effects like nausea, headaches, and drowsiness. Plus, they may interact with other meds you’re already taking.

On the other hand, you’ve got topical creams like lidocaine or prilocaine. These creams work by reducing sensitivity in the penis, which helps to delay ejaculation. And they’re applied directly to the area, so they’re less likely to cause side effects than oral meds. But, they can be a bit messy to use and may require reapplication during sex. And, they may not be as effective as oral meds.

In the end, it really depends on your individual needs and what you’re comfortable with. The most important thing is to talk with your healthcare professional and figure out the best option for you. They’ll be able to weigh the pros and cons and help you make the best decision.

Other premature ejaculation treatment options

If you’re not comfortable with taking any form of medication to help treat premature ejaculation there are plenty of natural ways to do so. We have covered them extensively in other articles so go check them out if you’re interested in understanding how. In this article we’ll just give you a few suggestions on how you can:


Is it really possible to help overcome premature ejaculation with mindfulness? Yes, it is! You see a lot of the causes of premature ejaculation are actually from a psychological perspective. So control the mind and you can help control your PE!


Can abstinence can help premature ejaculation?, well although It is not certain, and it often has the opposite affect for most guys. There can be some advantages to avoiding sexual intimacy that could potentially help some men to prolong their performance, including a reduction in stress and anxiety. But if you don’t fancy trying this one, yeah I get it, neither do I!

Diet and wellbeing

There are certain tweaks to your lifestyle you can make to give you the best chance of lasting as long in bed as possible. A few of these include getting enough exercise daily and eating the right foods that can increase your sex drive.


In conclusion, premature ejaculation is a frustrating and stressful sexual dysfunction for men to experience, however, there are a variety of medications and treatments available to help manage it. 

In this article, we discussed the different oral medications that are commonly used to treat premature ejaculation, specifically selective serotonin reuptake inhibitors (SSRIs) like dapoxetine and fluoxetine, as well as the opioid tramadol. 

Topical creams, like lidocaine or prilocaine, work by reducing sensitivity on the penis, which can delay ejaculation. The good thing is that it’s applied directly to the area and it tends to have fewer side effects than oral medications, so you don’t have to worry about feeling sick or anxious. And let’s be real, no one wants to feel sick or anxious during intimate moments, right?

The downside is that it can be a bit messy to use and might require reapplication during intercourse, which could be a bit of a mood killer. But, hey, if it helps you last longer, then it’s worth it!

While both of these medications can be effective in treating premature ejaculation, it’s important to understand the potential side effects and risks associated with each one and discuss them with a medical professional before starting any treatment. 

Each patient is unique and a healthcare professional would be able to assess your condition and find the right medication for you and recommend the right dosage to achieve the best results for you.

Dr. Frehiwot Tekie

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